Contents: Anastrazole

Indication/Uses: Treatment of hormone receptor-positive advanced breast cancer in postmenopausal women
Adjuvant treatment of hormone receptor-positive early invasive breast cancer in postmenopausal women
Adjuvant treatment of hormone receptor-positive early invasive breast cancer in postmenopausal women who have received 2 to 3 years of adjuvant tamoxifen

Dosage/Direction for Use: Treatment of hormone receptor-positive advanced breast cancer in postmenopausal women
Adjuvant treatment of hormone receptor-positive early invasive breast cancer in postmenopausal women
Adjuvant treatment of hormone receptor-positive early invasive breast cancer in postmenopausal women who have received 2 to 3 years of adjuvant tamoxifen

Dosage Details / Administration: Oral.Adjuvant therapy for postmenopausal women with hormone receptor positive early breast cancer, Breast cancer in postmenopausal women
Adult: As monotherapy in hormone receptor-positive advanced cases or in patients with disease progression following tamoxifen therapy: 1 mg once daily. Treatment may be continued up to 5 years for adjuvant therapy or until tumour progression for advanced breast cancer.

May be taken with or without food.

Contraindications: As monotherapy in pre-menopausal women with breast cancer. Severe renal impairment (CrCl <20 mL/min). Pregnancy and lactation.

Special Precaution: Patient with hyperlipidaemia; pre-existing osteopenia, ischaemic cardiac disease. Moderate to severe hepatic or mild to moderate renal impairment.

Adverse Reactions: hypercholesterolaemia, hypersensitivity reactions (e.g. anaphylaxis, angioedema, urticaria), ischaemic heart disease.
Blood and lymphatic system disorders: Lymphoedema.
Cardiac disorders: Angina pectoris, dyspnoea, chest pain.
Eye disorders: Cataract.
Gastrointestinal disorders: Gastrointestinal distress, anorexia, nausea, vomiting, constipation, diarrhoea, abdominal pain, dyspepsia, gastrointestinal disease, xerostomia.
General disorders and administration site conditions: Fatigue, pain, weakness.
Injury, poisoning and procedural complications: Bone fracture, accidental injury.
Investigations: Weight gain.
Metabolism and nutrition disorders: Oedema.
Musculoskeletal and connective tissue disorders: Arthritis, myalgia, arthralgia, back pain, ostealgia.
Nervous system disorders: Headache, dizziness, paraesthesia, carpal tunnel syndrome.
Psychiatric disorders: Mood disorder, depression, insomnia, anxiety.
Renal and urinary disorders: UTI.
Reproductive system and breast disorders: Pelvic pain, mastalgia, vulvovaginitis, vaginal dryness or bleeding.
Respiratory, thoracic and mediastinal disorders: Pharyngitis, cough, flu-like symptoms, sinusitis.
Skin and subcutaneous tissue disorders: Rash.
Vascular disorders: Vasodilation, hypertension, hot flushes.